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The evaluation of these missense mutations using in silico tools is described in (Additional file 3: Table S3) together with the evaluation of selected missense mutations identified in the genes analysed, . DNA analysis was performed in patient’s parents; her father carries p. On the basis of the in silico analyses and inheritance in the patient’s family, we suppose that p. Patient 92 is homozygous for the SGCB mutation p.
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